Flavokawain A suppresses the vasculogenic mimicry of HCC by inhibiting CXCL12 mediated EMT

FKA attenuated proliferation, invasion and metastatic and reversed EMT in HCC via PI3K/Akt/HIF-1α/NF-κB/Twist1 pathway by targeting CXCL12. This study proposed that FKA may be a candidate drug and prospective strategy for HCC therapy.