Cobalt‐Catalyzed Enantioselective Hydrotrifluoromethoxylation of Aromatic Alkenes

The construction of optically pure benzyl trifluoromethoxy (OCF3) compounds continues to present challenges, due to limited enantioselectivity‐control or the necessity for OCF3‐containing substrates of the only two previous reports. Herein, we have developed a salen‐Co‐catalyzed enantioselective hydrotrifluoromethoxylation reaction involving aromatic alkenes and trifluoromethyl arylsulfonate (TFMS). This method effectively produces a range of chiral benzyl trifluoromethoxy compounds with enantiomeric excesses ranging from 75% to 99%.