单线态氧
光动力疗法
材料科学
光化学
辐照
纳米技术
单重态
光敏剂
氧气
光电子学
化学
有机化学
原子物理学
物理
核物理学
激发态
作者
Yingyong Ni,Junjun Wang,Wenming Ai,Zhipeng Yu,Xiaojiao Zhu,Wei Wang,Xiang Sun,Qiong Zhang,Xingxing Chen,Manzhou Zhu,Hongping Zhou
标识
DOI:10.1002/adom.202302834
摘要
Abstract Commercial photosensitizers (PSs) present great potential in the field of clinical photodynamic therapy (PDT) yet face a formidable challenge owing to the extremely short lifespan of singlet oxygen ( 1 O 2 ). Herein, the 1 O 2 slow‐release “platform” is proposed based on an anthracene‐groups functionalized D‐π‐A system ( AIC ), which can capture and slowly release 1 O 2 produced by commercial PSs. Meanwhile, the reversible chemical process between AIC and 1 O 2 is demonstrated by a series of optical experiments and high‐resolution mass spectrum. Remarkably, by virtue of 1 O 2 slow‐release “platform”, the sustaining mitochondrial autophagy and cell apoptosis still take place when the laser is cut off with a short period of irradiation, reducing the side effect of sustained irradiation. In general, the construction of 1 O 2 slow‐release platform opens up exciting opportunities for improving the PDT effect of commercial PSs.
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