增强子
癌症
医学
内科学
生物
遗传学
转录因子
基因
作者
Yizhou Huang,Yanfei Huo,Long-Sun Huang,Long Zhang,Yanxiu Zheng,Nasha Zhang,Ming Yang
标识
DOI:10.1016/j.mrrev.2024.108489
摘要
Gastric cancer (GC) is the fifth most prevalent malignancy and the third leading cause of cancer-related mortality globally. Despite intensive efforts to enhance the efficiencies of various therapeutics (chemotherapy, surgical interventions, molecular-targeted therapies, immunotherapies), the prognosis for patients with GC remains poor. This might be predominantly due to the limited understanding of the complicated etiology of GC. Importantly, epigenetic modifications and alterations are crucial during GC development. Super-enhancers (SEs) are a large cluster of adjacent enhancers that greatly activate transcription. SEs sustain cell-specific identity by enhancing the transcription of specific oncogenes. In this review, we systematically summarize how SEs are involved in GC development, including the SE landscape in GC, the SE target genes in GC, and the interventions related to SE functions for treating GC.
科研通智能强力驱动
Strongly Powered by AbleSci AI