化学
试剂
联轴节(管道)
过渡金属
组合化学
化学物理
纳米技术
计算化学
有机化学
催化作用
冶金
材料科学
作者
Patrick S. Fier,Suhong Kim
摘要
We report the design and development of a transition-metal-free cross-coupling reaction of phenols and primary amines using a simple and readily available multifunctional reagent. The reactions work by induced proximity and electronic activation of both the nucleophile and the electrophile for net dehydrative C–N coupling reactions. Notably, the reactions do not involve the use of a transition metal for C–N bond formation, preactivation of the phenol electrophile, or exclusion of air or moisture. The mild conditions tolerate a broad range of functional groups and allow for this to be applied to the late-stage functionalization of complex substrates with a wide scope of coupling partners.
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