选择性拼接
拼接因子
RNA剪接
生物
外显子
生物发生
癌变
计算生物学
遗传学
基因
机制(生物学)
细胞生物学
核糖核酸
认识论
哲学
作者
Rong Jia,Zhi-Ming Zheng
摘要
Serine/arginine rich splicing factor 3 (SRSF3) is an important multi-functional splicing factor, and has attracted increasing attentions in the past thirty years.The importance of SRSF3 is evidenced by its impressively conserved protein sequences in all animals and alternative exon 4 which represents an autoregulatory mechanism to maintain its proper cellular expression level.New functions of SRSF3 have been continuously discovered recently, especially its oncogenic function.SRSF3 plays essential roles in many cellular processes by regulating almost all aspects of RNA biogenesis and processing of many target genes, and thus, contributes to tumorigenesis when overexpressed or disregulated.This review updates and highlights the gene, mRNA, and protein structure of SRSF3, the regulatory mechanisms of SRSF3 expression, and the characteristics of SRSF3 targets and binding sequences that contribute to SRSF3's diverse molecular and cellular functions in tumorigenesis and human diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI