A field study assessed the efficacy of insecticides against pink bollworm of cotton. Spinosad 45SC treated cotton had the lowest infestation at 23.95% in the first spray, while cypermethrin 25EC had a 26.06% infestation in the second spray. Emamectin benzoate 5SG and spinosad 45SC were the most potent insecticides for locule damage reduction. Emamectin benzoate 5SG had 70.54% mortality in the first spray, while spinosad 45SC had 76.2% mortality in the second spray. Emamectin benzoate 5SG, spinosad 45SC, and cypermethrin 25EC were the most effective insecticides overall.