Sustainable Synthesis of Diverse 1,1-Aminosilane Libraries Using a Multicomponent Cu-Catalyzed Reaction

Herein, we report a high-yielding, cost-effective, operationally simple, and readily scalable Cu-catalyzed multicomponent reaction for the synthesis of 1,1-aminosilanes from feedstock amine and aldehyde reagents. This method is compatible with aliphatic, aromatic, and heteroaromatic aldehydes and primary and secondary amines and is adaptable to the late-stage modification of FDA approved drugs and their direct precursors. Additionally, this method benefits from low catalyst loadings, mild reaction conditions, equimolar reagent concentrations, and the synthesis of air-stable products.