等离子体子
化学
胶体金
纳米技术
拉曼散射
生物分析
DNA
临床前影像学
DNA折纸
纳米颗粒
体内
DNA纳米技术
拉曼光谱
纳米结构
材料科学
光电子学
光学
物理
生物化学
生物技术
生物
作者
Yan Fei Tan,Jianxing Zhou,Xiaotong Xing,Junren Wang,Jinkun Huang,Huiyu Liu,Jiajie Chen,Mingjie Dong,Xiang Qin,Haifeng Dong,Xueji Zhang
标识
DOI:10.1021/acs.analchem.3c00775
摘要
Controllable self-assembly of the DNA-linked gold nanoparticle (AuNP) architecture for in vivo biomedical applications remains a key challenge. Here, we describe the use of the programmed DNA tetrahedral structure to control the assembly of three different types of AuNPs (∼20, 10, and 5 nm) by organizing them into defined positioning and arrangement. A DNA-assembled “core–satellite” architecture is built by DNA sequencing where satellite AuNPs (10 and 5 nm) surround a central core AuNP (20 nm). The density and arrangement of the AuNP satellites around the core AuNP were controlled by tuning the size and amount of the DNA tetrahedron functionalized on the core AuNPs, resulting in strong electromagnetic field enhancement derived from hybridized plasmonic coupling effects. By conjugating with the Raman molecule, strong surface-enhanced Raman scattering photoacoustic imaging signals could be generated, which were able to image microRNA-21 and tumor tissues in vivo. These results provided an efficient strategy to build precision plasmonic superstructures in plasmonic-based bioanalysis and imaging.
科研通智能强力驱动
Strongly Powered by AbleSci AI