电流(流体)
相(物质)
寡核苷酸
材料科学
计算机科学
工程类
化学
生物
电气工程
遗传学
DNA
有机化学
作者
Yogesh S. Sanghvi,Lucia Ferrazzano,Walter Cabri,Alessandra Tolomelli
出处
期刊:Royal Society of Chemistry eBooks
[The Royal Society of Chemistry]
日期:2024-10-18
卷期号:: 228-247
标识
DOI:10.1039/9781837674541-00228
摘要
Our ability to automate the assembly of synthetic oligonucleotides has transformed the drug discovery landscape in an unprecedented manner. Undoubtedly, the fast speed, wide range of scalability, and high quality of oligonucleotides have been the key drivers of phenomenal growth over the years. This progress is self-evident from more than 20 US Food and Drug Administration (FDA)-approved drugs and over 150 ongoing clinical trials with oligonucleotide-based molecules. It is anticipated that several high-volume products will reach the market in this decade. Although there is clear evidence of advances in the automated synthesis of these products, the implementation of sustainable processes has been slow. This chapter summarizes the status of technologies that have been put into practice to reduce the undesirable environmental impact while improving overall sustainability. An update on emerging process improvements is also presented that may have a profound impact on reducing the process mass intensity (PMI), leading to greener manufacturing protocols for oligonucleotides.
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