Remote enantioselective desymmetrization of cyclohexanone with carbonyl 1,2-transposition

In this issue of Chem Catalysis, Ye and co-workers present a bisguanidinium-catalyzed method involving an intramolecular carbonyl 1,2-transposition for the remote enantioselective desymmetrization of prochiral cyclohexanone. The comprehensive mechanistic experiments, coupled with density functional theory (DFT) calculations, lay a robust foundation for future advancements in functional-group transposition.