多重耐药
阿霉素
槲皮素
药理学
细胞内
医学
化学
癌症研究
抗药性
内科学
生物
化疗
生物化学
微生物学
抗氧化剂
作者
Haofei Zhou,Ye Yuan,Zhexu Wang,Zexin Ren,Mixia Hu,JingKun Lu,Hongxia Gao,Cheng Pan,Wenjie Zhao,Bo Zhu
标识
DOI:10.1016/j.colsurfa.2022.130654
摘要
Multidrug resistance (MDR) greatly hinders the efficacy of chemotherapy in a variety of hematological malignancies and solid tumors. Traditionally, Quercetin (Que) based co-delivery drugs strategies show lower water solubility and lack of motion ability for drugs active transfer. In order to overcome this disadvantage, we have developed a Janus nanomotors [email protected](DQ) for targeted combination therapy. The combined strategy could increase the intracellular accumulation of the two drugs (quercetin and doxorubicin) through the high-speed motion of the motor and higher killing rate of Dox on MCF-7/Adr cells by using quercetin. By reversing Dox resistance, [email protected](DQ), could achieve lower RI values (8.1) and higher RF values (6.8) in MCF-7/Adr cells compared to free Dox, which means [email protected] (DQ) is effective against multidrug resistance. This work exhibits a novel nanoplatform, which could not only load chemotherapy drugs efficiently, but could also improve the effect of chemotherapy drugs by overcoming MDR.
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