AIM The changes of nailfold microcirculation in patients with peptic ulcer(PU)were observed.METHODS The nailfold microcirculation of 36 patients with PU was observed with XG-5BI microcirculation video cameracomputer system.The statistical method of multiple quantitative evaluation was used.RESULTS On the nailfold microcirculation in PU patients,the configuration of loops became more deformed,the color of bloodmore darkened,the papillae more flattened,the speed of loops of blood flow much slower than those of control group(P 0.01).The total score in PU was significantly higher than that of the control group.CONCLUSIONS The observation indicates that the nailfold microcirculation in PU patients is significantly abnormal.