动脉硬化
脉冲波速
糖基化
医学
C反应蛋白
内科学
2型糖尿病
脉搏波分析
内分泌学
炎症
糖尿病
心脏病学
受体
血压
作者
Xiao Zhang,Jing Liu,Chee Fang Sum,Yeoh Lee Ying,Subramaniam Tavintharan,Xiao Wei Ng,Chang Su,Sui Pheng Low,Simon Bm Lee,Wern Ee Tang,Su Chi Lim
标识
DOI:10.1177/1479164116635021
摘要
To examine the relationship between inflammation and central arterial stiffness in a type 2 diabetes Asian cohort.Central arterial stiffness was estimated by carotid-femoral pulse wave velocity and augmentation index. Linear regression model was used to evaluate the association of high-sensitivity C-reactive protein and soluble receptor for advanced glycation end products with pulse wave velocity and augmentation index. High-sensitivity C-reactive protein was analysed as a continuous variable and categories (<1, 1-3, and >3 mg/L).There is no association between high-sensitivity C-reactive protein and pulse wave velocity. Augmentation index increased with high-sensitivity C-reactive protein as a continuous variable (β = 0.328, p = 0.049) and categories (β = 1.474, p = 0.008 for high-sensitivity C-reactive protein: 1-3 mg/L and β = 1.323, p = 0.019 for high-sensitivity C-reactive protein: >3 mg/L) after multivariable adjustment. No association was observed between augmentation index and soluble receptor for advanced glycation end products. Each unit increase in natural log-transformed soluble receptor for advanced glycation end products was associated with 0.328 m/s decrease in pulse wave velocity after multivariable adjustment (p = 0.007).Elevated high-sensitivity C-reactive protein and decreased soluble receptor for advanced glycation end products are associated with augmentation index and pulse wave velocity, respectively, suggesting the potential role of systemic inflammation in the pathogenesis of central arterial stiffness in type 2 diabetes.
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