Objective: To evaluate the applied value of CT guiding in the treatment of liver cancer with radiofrequency ablation.Methods: To ablate liver cancer of 16 cases with radiofrequency ablation by whole body CT-RILI.Results: The success rate of 16 cases under CT guiding was 93.8% and the total alleviater rate was 93.8%.Conclusion: CT guding is the optimal method in radiofrequency ablation for Liver cancer.