Effects of Allicin on Hemorheology and Physiological Properties of Erythrocytes in Acute Blood-stagnated Rats

Objective To explore the effects of allicin on hemorheology and physiological properties of erythrocytes.Methods We established the rat models of acute hyperviscosity and collected artery blood samples.Then we examined the hemorheology index and erythrocyte aggregation index by the viscosity methods,detected the erythrocyte filtration index by the nuclear pore film,determined erythrocyte membrane fluidity by the fluorescence polarization and performed erythrocyte osmotic fragility test.The difference between the allicin intrapertoneal injection group and the untreatment group was observed.Results In comparison with the untreatment group,all the high-,medium-and low-dose groups of allicin treatment had a decline in the enhancement of whole blood viscosity in rats with blood stasis(P0.01, P0.05).In the high-and medium-dose groups,the plasma viscosity significantly decreased(P0.05) and had the dose-effect relationship.In the high-dose group,the hematocrit greatly decreased(P0.05) and the erythrocyte deformability increased(P0.05).In the medium-and low-dose groups,the erythrocyte aggregation index decreased.All dose of allicin had effect on the increase of erythrocyte osmotic fragility and the decrease of erythrocyte membrane fluidity,but no significance was detected.Conclusion Allicin may increase the erythrocyte deformability,decrease the whole blood viscosity and improve the blood rheological properties and it can be used in the treatment of blood stasis.