OBJECTIVE: To explore the effect of Huangzhi oral liquid on platelet aggregation.METHODS: The platelet aggregation in rabbits was determined by turbidimetry and the bleeding time of mice was measured. RESULTS: Huangzhi oral liquid inhibited the platelet aggregation induced by adenosine diphosphate (ADP), arachidonic acid (AA) or PagVR (P0.01) and prolonged the bleeding time of mice.CONCLUSION: The platelet function can be inhibited by Huangzhi oral liquid.