Analysis of relationship between clinical stages of cirrhosis with platelet and blood coagulation function after chronic hepatitis B

Objective To understand the relationship between clinical stages and development of cirrhosis with platelet and blood coagulation function after chronic hepatitis B and its rule change.Methods With the retrospective analysis method,the detection results of PT,APTT,Fib and PLT in 123 inpatients with different clinical stages of cirrhosis after chronic hepatitis B were collected and compared with 31 healthy control for statistical analysis.Results PT and APTT in the groups of compensation and decompensation of cirrhosis after chronic hepatitis B were delayed greatly,Fib level and the quantity of PLT were decreased obviously,compared with normal control group.The difference between these groups was significant either compensation group or decompensation group of cirrhosis(P0.05).PT and APTT in the group of decompensation of cirrhosis after chronic hepatitis B were delayed,Fib level and the quantity of PLT were decreased,compared with compensation group.The difference between the two groups was significant(P0.05).Conclusion The blood coagulation function and platelet are closely related with the development of cirrhosis after chronic hepatitis B.Understanding the degree of functional lesion in liver has some diagnostic and therapeutic significance for judging the prognosis of cirrhosis.