"Antibacterial Activity of Nanomaterials Synthesized From Plant Extracts Against Methicillin Resistant Staphylococcus aureus (MRSA)"

Methicillin resistant Staphylococcus aureus (MRSA) are resistant to all β-lactam antibiotics and patients suffering from MRSA infections may lead to higher mortality rate and prolonged antibiotic therapy. Use of metallic nanoparticles treating infections caused by antibiotic resistant strains is a new paradigm. Sesbania grandiflora and Solanaum xanthocarpum were used for the synthesis of silver nanoparticles (Ag-NPs). A total of 55 strains were isolated from hospital environments in which 12 were identified as MRSA. Antibacterial activity of the green synthesized Ag-NPs against MRSA was assessed by determining the minimal inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and by measuring the dynamic growth curve of the bacteria. Further, toxicity assay of synthesized Ag-NPs on HeLa cell lines were performed. The MIC and MBC values of S.