Transmembrane G Protein-Coupled Receptor (TGR5) May Oppose the Effects of Nuclear Farnesoid X Receptor (FXR) in the Intestine

Luminal bile acids induce intestinal epithelial effects through the transmembrane G protein-coupled receptor (TGR5) and the nuclear farnesoid X receptor (FXR). We hypothesize that TGR5 and FXR act in opposition to one another in the small intestines.