级联
胰岛素
胰岛素释放
纳米技术
输送系统
材料科学
生物医学工程
化学
糖尿病
医学
内科学
色谱法
内分泌学
1型糖尿病
作者
Yuqi Zhang,Jinqiang Wang,Jicheng Yu,Di Wen,Anna R. Kahkoska,Yue Lü,Xudong Zhang,John B. Buse,Zhen Gu
出处
期刊:Small
[Wiley]
日期:2018-02-26
卷期号:14 (14)
被引量:115
标识
DOI:10.1002/smll.201704181
摘要
Abstract Self‐regulating glucose‐responsive insulin delivery systems have great potential to improve clinical outcomes and quality of life among patients with diabetes. Herein, an H 2 O 2 ‐labile and positively charged amphiphilic diblock copolymer is synthesized, which is subsequently used to form nano‐sized complex micelles (NCs) with insulin and glucose oxidase of pH‐tunable negative charges. Both NCs are loaded into the crosslinked core of a microneedle array patch for transcutaneous delivery. The microneedle core is additionally coated with a thin sheath structure embedding H 2 O 2 ‐scavenging enzyme to mitigate the injury of H 2 O 2 toward normal tissues. The resulting microneedle patch can release insulin with rapid responsiveness under hyperglycemic conditions owing to an oxidative and acidic environment because of glucose oxidation, and can therefore effectively regulate blood glucose levels within a normal range on a chemically induced type 1 diabetic mouse model with enhanced biocompatibility.
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