Enantioselective Recognition of Calix[5]arene-based Artificial Receptor Bearing Chiral Macrocycle for Chiral Ethyltrimethylammonium Salts

Abstract Calix[5]arene-based artificial receptor 1 capped with chiral macrocycle 4 was synthesized and showed strong binding toward ethyltrimethylammonium salts via cation/π and hydrogen-bonding interactions. The calix[5]arene cavity provided the dissymmetric guest-binding environment in which chiral guests 6–14 were encapsulated in an enantioselective fashion.