SOD2
GSTP1公司
超氧化物歧化酶
膀胱癌
转录因子
基因表达
基因
生物
谷胱甘肽
免疫学
内科学
分子生物学
癌症研究
癌症
内分泌学
医学
氧化应激
酶
遗传学
生物化学
作者
Edyta Reszka,Zbigniew Jabłonowski,Edyta Wieczorek,Jolanta Gromadzińska,Ewa Jabłońska,Marek Sosnowski,Wojciech Wąsowicz
出处
期刊:Neoplasma
[AEPress, s.r.o.]
日期:2012-01-01
卷期号:60 (02): 123-128
被引量:10
摘要
Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is an oxidant-responsive transcription factor involved in induction of antioxidant genes. We assessed NRF2 and selected NRF2-modulated gene expression: glutathione S-transferase A1 and P1 (GSTA1 and GSTP1), mitochondrial superoxide dismutase (SOD2) in blood leukocytes of 51 bladder cancer patients and 90 control males. A significant up-regulation of SOD2 expression (P=0.002) was observed in leukocytes of patients. NRF2 expression was positively correlated with GSTP1 and with SOD2 mRNA level, both in patients and controls. These data suggest disturbances in SOD2 transcription in circulating blood leukocytes of males with bladder cancer. Moreover, concomitant constitutive expression of NRF2 and its target genes may suggest important role of NRF2 transcription factor in positive regulation of antioxidant genes, resulted in enhanced cytoprotection in human peripheral blood leukocytes.
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