器官发生
干细胞
生物
胚胎干细胞
有机体
细胞生物学
诱导多能干细胞
发育生物学
胚胎
成体干细胞
细胞分化
模式生物
遗传学
基因
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2008-12-05
卷期号:322 (5907): 1498-1501
被引量:169
标识
DOI:10.1126/science.1162782
摘要
The development of individual organs in animal embryos involves the formation of tissue-specific stem cells that sustain cell renewal of their own tissue for the lifetime of the organism. Although details of their origin are not always known, tissue-specific stem cells usually share the expression of key transcription factors with cells of the embryonic rudiment from which they arise, and are probably in a similar developmental state. On the other hand, the isolation of pluripotent stem cells from the postnatal organism has encouraged the formulation of models of embryonic and postnatal development that are at variance with the conventional ones. Possible explanations for the existence of such cells, and the issue of whether they also exist in vivo, are discussed.
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