Difluoromethylation of O‐, S‐, N‐, C‐Nucleophiles Using Difluoromethyltri(n‐butyl)ammonium Chloride as a New Difluorocarbene Source

Abstract Difluoromethyltri( n ‐butyl)ammonium chloride 1 was found to be an effective difluorocarbene reagent for O ‐, S ‐, N ‐, C ‐difluoromethylation under basic conditions. It is particularly remarkable that, when only 1.2 equivalent of reagent 1 was used, the difluoromethylated products were obtained in moderate to excellent yields.