Development of a new amino-protecting group, 2-adamantyloxycarbonyl (2-adoc), and its application to the solid-phase synthesis of protected peptides

A new ε-amino protecting group, 2-adamantyloxycarbonyl (2-Adoc) has been developed, and its application to the solid phase synthesis of the protected peptide has been demonstrated successfully in combination with Nα-fluoren-9-ylmethoxycarbonyl (Fmoc) protection and trifluoroacetic acid (TFA)-cleavable resin support.