代谢组学
生物标志物发现
生物标志物
鉴定(生物学)
计算生物学
计算机科学
数据科学
蛋白质组学
生物信息学
生物
生物化学
植物
基因
作者
William J. Griffiths,Therese Koal,Yuqin Wang,Matthias Kohl,David Enot,Hans‐Peter Deigner
标识
DOI:10.1002/anie.200905579
摘要
Metabolomics is a truly interdisciplinary field of science, which combines analytical chemistry, platform technology, mass spectrometry, and NMR spectroscopy with sophisticated data analysis. Applied to biomarker discovery, it includes aspects of pathobiochemistry, systems biology/medicine, and molecular diagnostics and requires bioinformatics and multivariate statistics. While successfully established in the screening of inborn errors in neonates, metabolomics is now widely used in the characterization and diagnostic research of an ever increasing number of diseases. In this Review we highlight important technical prerequisites as well as recent developments in metabolomics and metabolomics data analysis with special emphasis on their utility in biomarker identification and qualification, as well as targeted metabolomics by employing high-throughput mass spectrometry.
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