化学
乙二胺四乙酸
侧链
齿合度
金属
肽
氨基酸
螯合作用
氨基酸残基
组合化学
立体化学
相(物质)
高分子化学
肽序列
有机化学
生物化学
聚合物
基因
作者
Christopher M. Micklitsch,Qian Yu,Joel P. Schneider
标识
DOI:10.1016/j.tetlet.2006.06.128
摘要
A family of penta- and hexadentate metal ligating α-amino acids, suitably protected for Fmoc solid-phase chemistry, has been prepared. These residues incorporate the mono-amides of ethanolaminetriacetic acid, ethylenediaminetriacetic acid, and ethylenediaminetetraacetic acid as side chains. Side chains are tethered varying distances (n) from the Cα-carbon to allow metal binding events to occur at distinct distances from the peptide backbone. These residues are designed to allow the facile installation of metal chelates along a peptide backbone.
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