谷氨酸羧肽酶Ⅱ
前列腺癌
前列腺
增生
癌症研究
酶
PCA3系列
医学
癌症
化学
内科学
生物化学
作者
Rena G. Lapidus,Carol W. Tiffany,John T. Isaacs,Barbara S. Slusher
出处
期刊:The Prostate
[Wiley]
日期:2000-01-01
卷期号:45 (4): 350-354
被引量:110
标识
DOI:10.1002/1097-0045(20001201)45:4<350::aid-pros10>3.0.co;2-u
摘要
Prostate-specific membrane antigen (PSMA) is a glutamate carboxypeptidase that cleaves terminal carboxy glutamates from both the neuronal dipeptide N-acetylaspartylglutamate (NAAG) and gamma-linked folate polyglutamate. The prostate enzyme has activity in both the membrane and cytosolic fractions termed PSMA and PSMA', respectively.Using a NAAG hydrolytic radioenzymatic assay, we quantitated the enzymatic activity of PSMA and PSMA' in normal, benign prostatic hyperplasia (BPH), and prostate cancer (PC) tissues from radical prostatectomies. PSMA enzyme activity was evaluated in each tissue type and expressed per milligram protein and epithelial cell content.PSMA and PSMA' enzyme activities were significantly elevated in prostate cancer when compared to normal prostate tissue and BPH. Ratios of PSMA to PSMA' were also decreased in BPH as compared to cancerous and normal tissue.Prostate carcinogenesis is associated with an elevation in PSMA and PSMA' enzyme activity. In contrast, no such enhancement in PSMA activity is observed with benign neoplastic changes in BPH. Thus, the enhancement observed in prostate cancer is not simply related to a generalized prostatic hyperplasia, but is specific to its malignancy.
科研通智能强力驱动
Strongly Powered by AbleSci AI