Pathological Biomineralization of Kidney Stones

Research Article| December 01, 2007 Pathological Biomineralization of Kidney Stones Jeffrey A. Wesson; Jeffrey A. Wesson 1Nephrology Division, Department of Veterans Affairs Medical Center and the Medical College of Wisconsin 5000 West National Avenue Milwaukee, Wisconsin 53295, USA Search for other works by this author on: GSW Google Scholar Michael D. Ward Michael D. Ward 2Molecular Design Institute, Department of Chemistry New York University, 100 Washington Square East, Room 1001 New York, NY 10003-6688, USA E-mail: mdw3@nyu.edu Search for other works by this author on: GSW Google Scholar Author and Article Information Jeffrey A. Wesson 1Nephrology Division, Department of Veterans Affairs Medical Center and the Medical College of Wisconsin 5000 West National Avenue Milwaukee, Wisconsin 53295, USA Michael D. Ward 2Molecular Design Institute, Department of Chemistry New York University, 100 Washington Square East, Room 1001 New York, NY 10003-6688, USA E-mail: mdw3@nyu.edu Publisher: Mineralogical Society of America First Online: 09 Mar 2017 Online ISSN: 1811-5217 Print ISSN: 1811-5209 © 2007 by the Mineralogical Society of America Elements (2007) 3 (6): 415–421. https://doi.org/10.2113/GSELEMENTS.3.6.415 Article history First Online: 09 Mar 2017 Cite View This Citation Add to Citation Manager Share Icon Share Facebook Twitter LinkedIn Email Permissions Search Site Citation Jeffrey A. Wesson, Michael D. Ward; Pathological Biomineralization of Kidney Stones. Elements 2007;; 3 (6): 415–421. doi: https://doi.org/10.2113/GSELEMENTS.3.6.415 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyElements Search Advanced Search Abstract Kidney stones are aggregates of microcrystals, most commonly containing calcium oxalate monohydrate (COM) as the primary constituent. The formation of these aggregates in the renal tubules of the kidney and their attachment to epithelial cells lining the renal tubules are thought to involve adhesion events between COM crystal surfaces and urinary species that bind to these surfaces. The pathological behavior of COM is in stark contrast to calcium oxalate dihydrate (COD), a different mineral phase commonly found in voided urine but much less frequently in stones, and whose presence is thought to protect against stone formation. This observation suggests that the structure and composition of calcium oxalate crystal surfaces and the fundamental interactions of these surfaces with urinary species are crucial to unraveling the complex pathology of this debilitating disease. You do not have access to this content, please speak to your institutional administrator if you feel you should have access.