Dipyrone – a pain killer which may ‘kill’ aspirin's antiplatelet action

Aims: Acetylsalicylic acid (Aspirin®) is routinely used after CABG as antiplatelet agent. Since the pyrazole analgesic dipyrone (Novalgin®) is often co-administered with aspirin and also known to interact with cyclooxygenase, the target of aspirin, we hypothesized that a drug interaction between aspirin and novalgin may contribute to aspirin resistance.