认知
神经科学
中枢神经系统
调节性T细胞
认知功能衰退
免疫系统
转录组
生物
脑功能
T细胞
免疫学
医学
基因
基因表达
病理
遗传学
疾病
白细胞介素2受体
痴呆
作者
María Llorián-Salvador,Alerie Guzman de la Fuente
标识
DOI:10.1016/j.molmed.2023.05.001
摘要
Recent work from Lemaitre and colleagues leveraged a central nervous system (CNS)-specific gene delivery approach to expand regulatory T cells (Treg) in aged mice. CNS-restricted Treg expansion reversed age-related glial cell transcriptomic changes and prevented aspects of cognitive decline, unveiling immune modulation as a potential approach to protect cognitive function with age.
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