Syntheses of deuterium-labeled dihydroartemisinic acid (DHAA) isotopologues and mechanistic studies focused on elucidating the conversion of DHAA to artemisinin

Artemisia annua is a plant that produces dihydroartemisinic acid (DHAA), which undergoes a reaction with two molecules of O 2 to yield artemisinin, an endoperoxide-containing sesquiterpenoid used to treat malaria.