Recent advances in 3D printed cellulose-based wound dressings: A review on in vitro and in vivo achievements

Chronic wounds, especially diabetic ulcers, pose a significant challenge in regenerative medicine. Cellulose derivatives offer remarkable wound management properties, such as effective absorption and retention of wound exudates, maintaining an optimal moisture environment crucial for successful chronic wound regeneration. However, conventional dressings have limited efficacy in managing and healing these types of skin lesions, driving scientists to explore innovative approaches. The emergence of 3D printing has enabled personalized dressings that meet individual patient needs, improving the healing process and patient comfort. Cellulose derivatives meet the demanding requirements for biocompatibility, printability, and biofabrication necessary for 3D printing of biologically active scaffolds. However, the potential applications of nanocellulose and cellulose derivative-based inks for wound regeneration remain largely unexplored. Thus, this review provides a comprehensive overview of recent advancements in cellulose-based inks for 3D printing of personalized wound dressings. The composition and biofabrication approaches of cellulose-based wound dressings are thoroughly discussed, including the functionalization with bioactive molecules and antibiotics for improved wound regeneration. Similarly, the in vitro and in vivo performance of these dressings is extensively examined. In summary, this review aims to highlight the exceptional advantages and diverse applications of 3D printed cellulose-based dressings in personalized wound care.