乳酸菌
益生菌
生物
安慰剂
普雷沃菌属
厚壁菌
粪便
阴道
细菌性阴道病
肠道菌群
生理学
益生元
内科学
微生物学
医学
免疫学
食品科学
细菌
16S核糖体RNA
遗传学
替代医学
病理
发酵
作者
Xin-Yee Ang,Nurhanis Syazni Roslan,Noraini Ahmad,Suhaimi Yusof,Norhani Abdullah,Nik Norashikin Nik Ab Rahman,Jia Min Woon,Cindy Shuan Ju Teh,Svetoslav Dimitrov Todorov,Guoxia Liu,Min‐Tze Liong
出处
期刊:Beneficial Microbes
[Wageningen Academic Publishers]
日期:2023-11-23
卷期号:14 (5): 421-431
标识
DOI:10.1163/18762891-20220103
摘要
Abstract The development of probiotics has now included the areas along the gut-vaginal axis. We thus aimed to investigate the effects of lactobacilli probiotic to modulate and restore vaginal and gut microbiota of pregnant women with vaginal candidiasis (VC). A randomised, double-blind and placebo-controlled study was performed in 78 pregnant women with VC. Patients were randomised to either the probiotic (SynForU-HerCare) or placebo which were administered at baseline and continued for 8-weeks (two capsules/day of 9.5 log cfu/capsule). Microbiota profiles were assessed at time points of weeks-0, 4 and 8 for high vaginal swab and faecal samples. Shannon diversity index showed that after 8-weeks amid VC, a shift in microbial community compositional changes occurred in the high vaginal region at both genus ( ) and species ( ) levels, where the administration of probiotic prevented such a shift. These changes were mainly attributed to a decreased in abundance of Lactobacillus ( ) accompanied by increased abundance of Prevotella ( ) and Atopobium ( ) in the placebo group while the probiotic group remained unchanged over time. The administration of probiotics also prevented a reduced abundance of faecal phylum Firmicutes after 8-weeks as seen in the placebo group ( ), which also showed reduction at subsequent taxonomic levels of class, family, genera and species. VC has not only altered the microbiota of vagina regions but also gut microbiota profiles, causing lessening of gut microbiota that are crucial for gut nutrient availability, protection and immunity. The administration of lactobacilli probiotics has prevented such a shift, leading to better modulated gut and vaginal microenvironment amid VC. The study was registered at ClinicalTrials.gov: identifier number NCT03940612
科研通智能强力驱动
Strongly Powered by AbleSci AI