Construction of Biomimetic Nanochannel, Property Regulation, and Biomarker Detection

Abstract The significance of biomimetic nanochannel in the field of biosensors is gaining increasing recognition. The controllable construction of biomimetic nanochannels and their performance modulation have demonstrated great importance and obtained wide interest. The nanochannels offer high sensitivity, enabling sensors to swiftly identify target biomarkers in complex biological samples, with detection limits reaching the picomolar level. Furthermore, they demonstrate exceptional selectivity and reproducibility, making them ideal tools for biomarker detection. In recent years, biosensors utilizing biomimetic nanochannel have shown remarkable performance in detecting a wide range of biomarkers. This review aims to explore the opportunities and challenges associated with biomimetic nanochannel technology in biosensor applications, focusing on the construction and performance modulation of these nanochannels, as well as their applications in detecting nucleic acids, proteins, organisms, and small molecules. Providing forward‐looking insights into this cutting‐edge field is aspired, with particular emphasis on technological advancements, addressing current challenges, and discussing future trends.