长时程增强
神经科学
神经可塑性
树突棘
突触可塑性
神经营养因子
心理学
医学
生物
受体
内科学
海马结构
作者
Gioia Marino,Federica Campanelli,Giuseppina Natale,Maria De Carluccio,Federica Servillo,Elena Ferrari,Fabrizio Gardoni,Maria Emiliana Caristo,Barbara Picconi,Antonella Cardinale,Vittorio Loffredo,Francesco Crupi,Elvira De Leonibus,Maria Teresa Viscomi,Veronica Ghiglieri,Paolo Calabresi
出处
期刊:Science Advances
[American Association for the Advancement of Science]
日期:2023-07-14
卷期号:9 (28)
被引量:18
标识
DOI:10.1126/sciadv.adh1403
摘要
Intensive physical activity improves motor functions in patients with Parkinson's disease (PD) at early stages. However, the mechanisms underlying the beneficial effects of exercise on PD-associated neuronal alterations have not been fully clarified yet. Here, we tested the hypothesis that an intensive treadmill training program rescues alterations in striatal plasticity and early motor and cognitive deficits in rats receiving an intrastriatal injection of alpha-synuclein (α-syn) preformed fibrils. Improved motor control and visuospatial learning in active animals were associated with a recovery of dendritic spine density alterations and a lasting rescue of a physiological corticostriatal long-term potentiation (LTP). Pharmacological analyses of LTP show that modulations of N-methyl-d-aspartate receptors bearing GluN2B subunits and tropomyosin receptor kinase B, the main brain-derived neurotrophic factor receptor, are involved in these beneficial effects. We demonstrate that intensive exercise training has effects on the early plastic alterations induced by α-syn aggregates and reduces the spread of toxic α-syn species to other vulnerable brain areas.
科研通智能强力驱动
Strongly Powered by AbleSci AI