分子筛
化学
亚胺
脱水
催化作用
有机化学
冷凝
色谱法
化学工程
生物化学
热力学
物理
工程类
作者
Tomohiro Yasukawa,Harushi Nakajima,Ryusuke Masuda,Yasuhiro Yamashita,Shū Kobayashi
标识
DOI:10.1021/acs.joc.2c01411
摘要
Although the use of molecular sieves for imine synthesis is a common protocol, there have been no comprehensive studies on heat-drying methods. This can be crucial for reproducibility. It was found that molecular sieve 5A dried at 160 °C for 5 h under vacuum efficiently promoted the condensation of various ketones and amines to afford even relatively bulky ketimines. Several control experiments and analyses revealed that only a small amount of Brønsted acid sites was important for the activity, rather than dehydration ability. Other types of molecular sieves could be utilized for the reaction after treatment with water followed by heat drying. A continuous-flow acetalization reaction of alcohols using the activated molecular sieve 5A was also demonstrated.
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