PI3K/AKT/mTOR通路
糖尿病
医学
糖尿病性视网膜病变
雷帕霉素的作用靶点
糖尿病肾病
mTOR抑制剂的发现与发展
细胞生长
RPTOR公司
生物信息学
内科学
内分泌学
生物
信号转导
细胞生物学
遗传学
作者
S. Shanthi,Faheem Faheem
出处
期刊:Current Molecular Pharmacology
[Bentham Science]
日期:2023-08-01
卷期号:16 (5)
被引量:1
标识
DOI:10.2174/1874467215666221005123919
摘要
Mechanistic/Mammalian target of rapamycin (mTOR) orchestrates cellular homeostasis by controlling cell growth, proliferation, metabolism, and survival by integrating various growth factors, nutrients and amino acids. Eccentric synchronization of mTOR has been incriminated in various diseases/disorders like cancer, neurodegenerative disorders, and diabetes mellitus and its complications. Recent reports also highlight the role of mTOR in diabetes and its associated complications. This review tries to fathom the role of mTOR signaling in diabetes mellitus and its complications- diabetic cardiomyopathy, diabetic nephropathy, and diabetic retinopathy and highlights mTOR as a putative target for the development of novel anti-diabetic drug candidates.
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