化学
分析化学(期刊)
血红蛋白
分析物
电解质
平均差
色谱法
核医学
医学
内科学
置信区间
生物化学
电极
物理化学
作者
Antoine Puravet,Benjamin Rieu,Camille Phere,Samy Kahouadji,Bruno Pereira,Matthieu Jabaudon,Benjamin Andanson,Marina Braïlova,Vincent Sapin,Damien Bouvier
标识
DOI:10.1515/cclm-2023-0162
摘要
Abstract Objectives The objective of our study is to evaluate the effect of storage temperature and time to analysis on arterial blood gas parameters in order to extend the CLSI recommendations. Methods Stability of 12 parameters (pH, pCO₂, pO₂, Na + , K + , Ca 2+ , glucose, lactate, hemoglobin, oxyhemoglobin, carboxyhemoglobin, methemoglobin) measured by GEM PREMIER™ 5000 blood gas analyzer was studied at room temperature and at +4 °C (52 patients). The storage times were 30, 45, 60, 90 and 120 min. Stability was evaluated on the difference from baseline, the difference from the analyte-specific measurement uncertainty applied to the baseline value, and the impact of the variation on the clinical interpretation. Results At room temperature, all parameters except the lactate remained stable for at least 60 min. A statistically significant difference was observed for pH at T45 and T60 and for pCO 2 at T60 without modification of clinical interpretation. For lactate, clinical interpretation was modified from T45 and values were outside the range of acceptability defined by the measurement uncertainty. All parameters except pO 2 remained stable for at least 120 min at +4 °C. Conclusions A one-hour transport at room temperature is compatible with the performance of all the analyses studied except lactate. If the delay exceeds 30 min, the sample should be placed at +4 °C for lactate measurement. If the samples are stored in ice, it is important to note that the pO 2 cannot be interpreted.
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