类有机物
结直肠癌
多细胞生物
诱导多能干细胞
肿瘤微环境
癌症
生物
转化研究
肠上皮
LGR5型
计算生物学
癌症干细胞
细胞生物学
癌细胞
干细胞
肠粘膜
细胞
神经科学
胚胎干细胞
生物技术
基因
遗传学
作者
Musa Adebayo Idris,Maria Dalva Santos Alves,Robert M.W. Hofstra,Maxime M. Mahe,Veerle Melotte
标识
DOI:10.1016/j.bbcan.2021.188586
摘要
Modeling colorectal cancer (CRC) using organoids has burgeoned in the last decade, providing enhanced in vitro models to study the development and possible treatment options for this type of cancer. In this review, we describe both normal and CRC intestinal organoid models and their utility in the cancer research field. Besides highlighting studies that develop epithelial CRC organoid models, i.e. organoids without tumor microenvironment (TME) cellular components, we emphasize on the need for TME in CRC modeling, to help reduce translational disparities in this area. Also, we discuss the utilization of CRC organoids derived from pluripotent stem cells, as well as their potential to be used in cancer research. Finally, limitations and challenges in the current CRC organoids field, are discussed.
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