In article number 1909882, Samad Ahadian, Leonardo Morsut, Ali Khademhosseini, and co-workers highlight the great potential of tissue engineering approaches and synthetic biology principles to fabricate biological tissues and cellular constructs in a biomimetic and precise manner via the manipulation of cell behavior and function. Advanced biomaterials and biofabrication tools can also be employed to improve the functionality of engineered tissues for therapeutic and in vitro applications.