Synthesis and characterization of a series of phenyl piperazine based ligands

Abstract Piperazine based compounds are gaining more attention in today’s research as the piperazine nucleus is found in many biologically active compounds. Substitution in nitrogen atom of piperazine with a suitable fragment containing donor atoms, make it unique for versatile binding possibilities with metal ion. Piperazine derived ligands and their metal complexes have shown applications in different fields like antimicrobial, antioxidant, antihistaminic, anticancer, DNA binding and protein binding, catalyst in ring opening polymerization (ROP), etc. Metal-organic framework derived from piperazine based ligands has also been reported in the literature. This paper presents the synthesis, and characterization of a series of piperazine based ligands. The asymmetrical ligands have been synthesized by cyclization of bis-chloroethyl amine with suitable amine. Some of the representative metal complexes are also synthesized and characterized.