[Advances in the research of effects and regulatory mechanism of regulatory T cells in tissue injury and repair].

The repair strategy after organs injuries has always been a hot topic in the field of regenerative medicine. Traditional injury repair measures mainly promote tissue repair through mesenchymal stem cells and various growth factors, but these strategies have been constrained in the aspects of security and economy. Hence, there is an urgent need to find new ways to promote tissue repair and regeneration. There have been a lot of evidences showing that the immune system plays an important role in tissue regeneration and repair. In recent years, more and more studies have been done on adaptive immunity in tissue repair, especially the regulatory T cells. Some evidences indicate that regulatory T cells participate in damage tissue repair and regeneration of multiple organs and tissue. This review briefly introduces the new advances in the repair effects and regulatory mechanism of regulatory T cells in different organ injuries, in order to provide new ideas for designing advanced repair materials with good immunoregulatory functions.器官损伤后修复策略一直是再生医学领域研究的热点。传统的损伤修复方案多通过间充质干细胞及各种生长因子促进组织修复，但其受到安全性和经济性的制约，因此迫切需要寻找新的促进组织修复与再生的方法。目前已有较多研究证据显示，免疫系统在组织再生与修复中发挥着重要的作用。近年来，关于适应性免疫在组织修复中的研究日益增多，尤其是调节性T细胞，有资料提示其参与了多种脏器损伤修复与组织再生过程。本文概要介绍了调节性T细胞在不同脏器损伤中的修复效应及其调控机制新进展，旨在为未来设计出具有良好免疫调控性能的修复材料提供新思路。.