间充质干细胞
微泡
椎间盘
细胞生物学
退行性椎间盘病
干细胞
间质细胞
癌症研究
医学
再生医学
移植
生物
病理
小RNA
解剖
遗传学
内科学
替代医学
基因
作者
Gunawan Widjaja,Abduladheem Turki Jalil,Hendrik Setia Budi,Walid Kamal Abdelbasset,Syahril Efendi,Wanich Suksatan,Rauza Sukma Rita,Andri Praja Satria,Surendar Aravindhan,Marwan Mahmood Saleh,Mohammed Nader Shalaby,Alexei Valerievich Yumashev
标识
DOI:10.1016/j.intimp.2022.108537
摘要
Today, the application of mesenchymal stromal/stem cells (MSCs) and their exosomes to treat degenerative diseases has received attention. Due to the characteristics of these cells, such as self-renewability, differentiative and immunomodulatory effects, their use in laboratory and clinical studies shows promising results. However, the allogeneic transplantation problems of MSCs limit the use of these cells in the clinic. Scientists propose the application of exosomes to use from the therapeutic effect of MSCs and overcome their defects. These vesicles change the target cell behaviour and transcription profile by transferring various cargo such as proteins, mi-RNAs, and lipids. One of the degenerative tissue diseases in which MSCs and their exosomes are used in their treatment is intervertebral disc disease (IDD). Different factors such as genetics, nutrition, ageing, and environmental factors play a significant role in the onset and progression of this disease. These factors affect the cellular and molecular properties of the disc, leading to tissue destruction. Nucleus pulposus cells (NPCs) are among the most important cells involved in the pathogenesis of disc degeneration. MSCs exert their therapeutic effects by differentiating, reducing apoptosis, increasing proliferation, and decreasing senescence in NPCs. In addition, the use of MSCs and their exosomes also affects the annulus fibrosus and cartilaginous endplate cells in disc tissue and prevents disc degeneration progression.
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