白塞病
医学
唾液
内科学
胃肠病学
白细胞介素
一氧化氮
疾病
白细胞介素8
白细胞介素6
免疫学
炎症
细胞因子
作者
Zohra Hadjimi,Houda Belguendouz,Sarah Benchabane,Nour El Houda Ghozali,Manel Amri,Racha Kocheida,D. Hakem,Ahmed Biad,F. Otmani,Yasmine Kemikem,Malika Terahi,Chafia Touil–Boukoffa
出处
期刊:Endocrine, metabolic & immune disorders
[Bentham Science]
日期:2023-03-01
卷期号:23 (3): 347-355
被引量:1
标识
DOI:10.2174/1871530322666220512120948
摘要
Oral aphthosis is one of the major manifestations of Behçet's disease (BD), a chronic, multisystemic vasculitis. BD etio-pathogenicity related to oral health lack.This study investigated the possible relationships between poor oral hygiene, oral activity, disease severity and saliva's Interleukin (IL)-32, IL-6, IL-10 and nitric oxide (NO) levels in Behçet's patients to determine their role in disease prognosis and their potential therapeutic interest.Fifty-six patients with BD (22 orally active; 34 orally inactive) and 31 healthy subjects have been included in our study. Salivary levels of IL-32, IL-6, and IL-10 were measured using ELISA, while NO levels were assessed by modified Griess's method. Oral health status and disease severity scores were recorded for each participant. Kruskal-Wallis test and Spearman's test were performed for statistical analyses.We observed that the tested molecules were increased in BD patients compared to healthy controls (p˂0.05). Moreover, only IL-32 levels were associated with oral activity in patients (p˂0.05). Interestingly, the disease severity score was noted to be correlated positively and significantly with both IL-32 saliva levels (p˂0.01) and plaque index (p˂0.05) in BD patients. Furthermore, IL-32 levels were correlated with plaque index (p˂0.0001).Our results suggest that IL-32, IL- 6, IL-10 and NO were increased in saliva during BD. Our study indicated that IL-32 was associated with the genesis of oral ulcers in response to dental plaque. Ultimately, salivary IL-32 may serve as a prognostic biomarker and a possible therapeutic target for managing Behçet's disease severity.
科研通智能强力驱动
Strongly Powered by AbleSci AI