Catalytic Asymmetric β‐Oxygen Elimination

A catalytic enantioselective β-O-elimination is reported. The reaction design utilizes the symmetry of meso-ketene acetal substrates and proceeds in the presence of a chiral zirconocene catalyst. Furthermore, a regiodivergent β-O-elimination, the application in diol and amino alcohol synthesis, and a DFT-supported stereochemical analysis are presented.