纳米凝胶
单线态氧
超分子化学
活性氧
酶
化学
激活剂(遗传学)
癌症治疗
生物有机化学
生物物理学
氧气
生物化学
癌症
有机化学
生物
药物输送
遗传学
晶体结构
基因
作者
Qi Zhang,Jiaojiao Wu,Jingjing Wang,Xia Wang,Chuhan Wu,Mengwei Chen,Qing Wu,Maciej S. Lesniak,Yongli Mi,Yu Cheng,Qigang Wang
标识
DOI:10.1002/ange.201915118
摘要
Abstract Neutrophils can responsively release reactive oxygen species (ROS) to actively combat infections by exogenous stimulus and cascade enzyme catalyzed bio‐oxidation. A supramolecular nanogel is now used as an artificial neutrophil by enzymatic interfacial self‐assembly of peptides (Fmoc‐Tyr(H 2 PO 3 )‐OH) with magnetic nanoparticles (MNPs) and electrostatic loading of chloroperoxidase (CPO). The MNPs within the nanogel can elevate H 2 O 2 levels in cancer cells under programmed alternating magnetic field (AMF) similar to the neutrophil activator, and the loaded CPO within protective peptides nanolayer converts the H 2 O 2 into singlet oxygen ( 1 O 2 ) in a sustained manner for neutrophil‐inspired tumor therapy. As a proof of concept study, both the H 2 O 2 and 1 O 2 in cancer cells increase stepwise under a programmed alternating magnetic field. An active enzyme dynamic therapy by magnetically stimulated oxygen stress and sustained enzyme bio‐oxidation is thus shown with studies on both cells and animals.
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