化学
对映选择合成
催化作用
烯丙基重排
功能群
组合化学
基质(水族馆)
分子
有机化学
海洋学
地质学
聚合物
作者
Jingjing Geng,Deli Sun,Yenan Song,Weiqi Tong,Fan Wu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-03-02
卷期号:24 (9): 1807-1811
被引量:9
标识
DOI:10.1021/acs.orglett.2c00217
摘要
A nickel-catalyzed enantioconvergent reductive cross-coupling of α-chlorosulfones with vinyl bromides is described here. This strategy enables the enantioselective construction of chiral allylic sulfones from simple α-chlorosulfones and vinyl bromides. The mild reaction conditions lead to excellent functional group compatibility, as evidenced by the broad substrate scope and tolerance of complex bioactive molecules. Our preliminary mechanistic study suggests that this enantioselective vinylation process operates through a radical intermediate.
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