化学
倍半萜
立体化学
细胞毒性
碳骨架
二维核磁共振波谱
体外
生物化学
作者
Jun Chi,Wen‐Jun Xu,Shanshan Wei,Xiaobing Wang,Jixin Li,Hongliang Gao,Lingyi Kong,Jun Luo
出处
期刊:Organic Letters
[American Chemical Society]
日期:2019-01-17
卷期号:21 (3): 789-792
被引量:47
标识
DOI:10.1021/acs.orglett.8b04046
摘要
Two unprecedented lindenane sesquiterpene dimers, chlotrichenes A (1) and B (2), were obtained from Chloranthus holostegius var. trichoneurus. Their structures were characterized by NMR, ECD, and X-ray diffraction analysis. They possess a new type of spirocarboncyclic dimeric framework formed by endo-Diels–Alder reaction, and the structure of 1 features a unique 3/5/6/6/6/6/5/3-fused octacyclic skeleton by subsequently plausible epoxidation–cyclization reactions of 2. Compound 2 showed synergetic cytotoxicity with DOX on U2 OS cells (CI: 0.94 ± 0.03).
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